Advanced NMR techniques for structural characterization of heterocyclic structures

H and C NMR spectra remain the first tool used by chemists to perform the structure elucidation of their products on a routine basis. It is common to provide NMR data on both proton and carbon spectra based on one-dimensional experiments. The increasing complexicity of natural compounds and their synthetic related derivatives implies the use of some more recent 1D and 2D NMR techniques. The purpose of this publication is to describe the main H, C and N NMR features of three to six-membered heterocyclic compounds and also to discuss the application of several 1D and mainly 2D NMR techniques in the structure elucidation of these compounds. A brief discussion of these NMR techniques from the point of view of structural elucidation of organic compounds will be also considered. Correspondence/Reprint request: Dr. Artur M. S. Silva, Department of Chemistry, University of Aveiro, 3810-193 Aveiro Portugal. E-mail: [email protected] Diana C. G. A. Pinto et al. 398